Mertansine Inhibits mRNA Expression and Enzyme Activities of Cytochrome P450s and Uridine 5'-Diphospho-Glucuronosyltransferases in Human Hepatocytes and Liver Microsomes

Mertansine, a tubulin inhibitor, is used as the cytotoxic component of antibody−drug conjugates (ADCs) for cancer therapy. The effects of mertansine on uridine 5′-diphospho-glucuronosyltransferase (UGT) activities in human liver microsomes and its effects on the mRNA expression o...

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Váldodahkkit: Won-Gu Choi (Dahkki), Ria Park (Dahkki), Dong Kyun Kim (Dahkki), Yongho Shin (Dahkki), Yong-Yeon Cho (Dahkki), Hye Suk Lee (Dahkki)
Materiálatiipa: Girji
Almmustuhtton: MDPI AG, 2020-03-01T00:00:00Z.
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3rd Floor Main Library

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