Mertansine Inhibits mRNA Expression and Enzyme Activities of Cytochrome P450s and Uridine 5'-Diphospho-Glucuronosyltransferases in Human Hepatocytes and Liver Microsomes

Mertansine, a tubulin inhibitor, is used as the cytotoxic component of antibody−drug conjugates (ADCs) for cancer therapy. The effects of mertansine on uridine 5′-diphospho-glucuronosyltransferase (UGT) activities in human liver microsomes and its effects on the mRNA expression o...

Full description

Saved in:
Bibliographic Details
Main Authors: Won-Gu Choi (Author), Ria Park (Author), Dong Kyun Kim (Author), Yongho Shin (Author), Yong-Yeon Cho (Author), Hye Suk Lee (Author)
Format: Book
Published: MDPI AG, 2020-03-01T00:00:00Z.
Subjects:
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

Connect to this object online.

3rd Floor Main Library

Holdings details from 3rd Floor Main Library
Call Number: A1234.567
Copy 1 Available