Multi-Target Actions of Acridones from <i>Atalantia monophylla</i> towards Alzheimer's Pathogenesis and Their Pharmacokinetic Properties

• Main Authors: Pitchayakarn Takomthong (Author), Pornthip Waiwut (Author), Chavi Yenjai (Author), Aonnicha Sombatsri (Author), Prasert Reubroycharoen (Author), Luo Lei (Author), Ren Lai (Author), Suchada Chaiwiwatrakul (Author), Chantana Boonyarat (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ten acridones isolated from <i>Atalantia monophylla</i> were evaluated for effects on Alzheimer's disease pathogenesis including antioxidant effects, acetylcholinesterase (AChE) inhibition, prevention of beta-amyloid (Aβ) aggregation and neuroprotection. To understand the mechanism,...