Pharmacokinetics and Biodistribution of Human Serum Albumin-TIMP-2 Fusion Protein Using Near-Infrared Optical Imaging

• Main Authors: Mi-Sook Lee (Author), Young Han Kim (Author), Yeon Joo Kim (Author), Seung-Hae Kwon (Author), Jeong-kyu Bang (Author), Sang-Mok Lee (Author), Yun Seon Song (Author), Dae-Hyun Hahm (Author), Insop Shim (Author), Daeseok Han (Author), Song Her (Author)
• Format: Book
• Published: Frontiers Media S.A., 2011-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose TIMP-2 has been studied as an attractive cancer therapeutic candidate, and a TIMP-2 fusion protein (HSA/TIMP-2) displayed effective anticancer activity, despite a lack of information about its pharmacokinetics (PK) and biodistribution. The purpose of this work was to assess the PK and biodis...