Pharmacokinetics and Biodistribution of Human Serum Albumin-TIMP-2 Fusion Protein Using Near-Infrared Optical Imaging

• Autores principales: Mi-Sook Lee (Autor), Young Han Kim (Autor), Yeon Joo Kim (Autor), Seung-Hae Kwon (Autor), Jeong-kyu Bang (Autor), Sang-Mok Lee (Autor), Yun Seon Song (Autor), Dae-Hyun Hahm (Autor), Insop Shim (Autor), Daeseok Han (Autor), Song Her (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2011-10-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Purpose TIMP-2 has been studied as an attractive cancer therapeutic candidate, and a TIMP-2 fusion protein (HSA/TIMP-2) displayed effective anticancer activity, despite a lack of information about its pharmacokinetics (PK) and biodistribution. The purpose of this work was to assess the PK and biodis...