Hepatic COX1 loss leads to impaired autophagic flux and exacerbates nonalcoholic steatohepatitis

• Main Authors: Qian Yu (Author), Chang Li (Author), Qinghui Niu (Author), Jigang Wang (Author), Zhaodi Che (Author), Ke Lei (Author), He Ren (Author), Boyi Ma (Author), Yixing Ren (Author), Pingping Luo (Author), Zhuming Fan (Author), Huan Zhang (Author), Zhaohui Liu (Author), George L. Tipoe (Author), Jia Xiao (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mechanisms underlying autophagic defects in nonalcoholic steatohepatitis (NASH) remain largely unknown. We aimed to elucidate the roles of hepatic cyclooxygenase 1 (COX1) in autophagy and the pathogenesis of diet-induced steatohepatitis in mice. Human nonalcoholic fatty liver disease (NAFLD) liv...