Induction of fibroblast growth factor 21 does not require activation of the hepatic X-box binding protein 1 in mice

Objective: Fibroblast growth factor 21 (FGF21), a key regulator of the metabolic response to fasting, is highly induced by endoplasmic reticulum (ER) stress. The X-box binding protein 1 (Xbp1) is one of several ER stress proteins that has been shown to directly activate the FGF21 promoter. We aimed...

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Main Authors: Shantel Olivares (Author), Anne S. Henkel (Author)
Format: Book
Published: Elsevier, 2017-12-01T00:00:00Z.
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