The mediating role of metabolites between gut microbiome and Hirschsprung disease: a bidirectional two-step Mendelian randomization study

BackgroundGut microbiome (GM) was observed to be associated with the incidence of Hirschsprung disease (HD). However, the effect and mechanism of GM in HD is still unclear. To investigate the relationship between GM and HD and the effect of metabolites as mediators, a bidirectional two-step Mendelia...

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Hauptverfasser: Zhe Wang (VerfasserIn), Bingjun Gao (VerfasserIn), Xiao Liu (VerfasserIn), Aiwu Li (VerfasserIn)
Format: Buch
Veröffentlicht: Frontiers Media S.A., 2024-08-01T00:00:00Z.
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