Immunocytochemical Characterization of Alzheimer's Disease Hallmarks in APP/PS1 Transgenic Mice Treated with a New Anti-Amyloid-β Vaccine

• Main Authors: Ivan Carrera (Author), Ignacio Etcheverria (Author), Yi Li (Author), Lucia Fernandez-Novoa (Author), Valter Lombardi (Author), Carmen Vigo (Author), Hector H. Palacios (Author), Valery V. Benberin (Author), Ramon Cacabelos (Author), Gjumrakch Aliev (Author)
• Format: Book
• Published: University Library System, University of Pittsburgh, 2014-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: APP/PS1 double-transgenic mouse models of Alzheimer's disease (AD), which overexpress mutated forms of the gene for the human amyloid precursor protein (APP) and presenilin 1 (PS1), have provided robust neuropathological hallmarks of an AD-like pattern at early ages. This study ai...