Discovery and Validation of a Compound to Target Ewing's Sarcoma

• Main Authors: Ellie Esfandiari Nazzaro (Author), Fahad Y. Sabei (Author), Walter K. Vogel (Author), Mohamad Nazari (Author), Katelyn S. Nicholson (Author), Philip R. Gafken (Author), Olena Taratula (Author), Oleh Taratula (Author), Monika A. Davare (Author), Mark Leid (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ewing's sarcoma, characterized by pathognomonic t (11; 22) (q24; q12) and related chromosomal ETS family translocations, is a rare aggressive cancer of bone and soft tissue. Current protocols that include cytotoxic chemotherapeutic agents effectively treat localized disease; however, these aggr...