A novel SYBR-based duplex qPCR for the detection of gene dosage: detection of an <it>APC</it> large deletion in a familial adenomatous polyposis patient with an unusual phenotype

• Main Authors: Torrezan Giovana (Author), da Silva Felipe Cavalcanti (Author), Krepischi Ana Cristina (Author), dos Santos Érika Maria (Author), Rossi Benedito (Author), Carraro Dirce (Author)
• Format: Book
• Published: BMC, 2012-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Familial adenomatous polyposis (FAP) is a hereditary colorectal cancer syndrome caused by a loss of function of the <it>APC</it> gene. Large deletions in <it>APC</it> are a common cause of FAP; despite the exi...