Prediction of the Antiinflammatory Activity of New S-alkyl Derivatives of 1,2,4-triazol-3-thiones Using the PASS Computer Program and Molecular Docking

• Main Authors: Natalya Mykolaivna Chalenko (Author), Anna Olegovna Syrovaya (Author), Natalya P Kobzar (Author), Maryna V Rakhimova (Author), Irina A Sych (Author), Igor Vladimirovich Sych (Author)
• Format: Book
• Published: Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The strategy of rational approaches to the search for selective COX-2 inhibitors as potential antiinflammatory agents has been proposed and elaborated. It is based on the use of PASS-prediction and molecular docking. The choice of the basic structure of 4-amino-3-thio-1,2,4-triazole as a promising o...