Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer

• Main Authors: David Gonzalez (Author), Joaquin Mateo (Author), Albrecht Stenzinger (Author), Federico Rojo (Author), Michelle Shiller (Author), Alexander W Wyatt (Author), Frédérique Penault‐Llorca (Author), Leonard G Gomella (Author), Ros Eeles (Author), Anders Bjartell (Author)
• Format: Book
• Published: Wiley, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Analysis of the genomic landscape of prostate cancer has identified different molecular subgroups with relevance for novel or existing targeted therapies. The recent approvals of the poly(ADP‐ribose) polymerase (PARP) inhibitors olaparib and rucaparib in the metastatic castration‐resistant...