Toxicokinetics of Arenobufagin and its Cardiotoxicity Mechanism Exploration Based on Lipidomics and Proteomics Approaches in Rats

• Main Authors: Lijuan Zhao (Author), Lingyu Han (Author), Xiaolu Wei (Author), Yanyan Zhou (Author), Yanqiong Zhang (Author), Nan Si (Author), Hongjie Wang (Author), Jian Yang (Author), Baolin Bian (Author), Haiyu Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Arenobufagin (ArBu), one of the main active bufadienolides of toad venom with cardiotonic effect, analgesic effect, and outstanding anti-tumor potentiality, is also a potential cardiotoxic component. In the present study, the cardiac effect of ArBu and its underlying mechanism were explored by integ...