Biotin-Decorated PAMAM G4.5 Dendrimer Nanoparticles to Enhance the Delivery, Anti-Proliferative, and Apoptotic Effects of Chemotherapeutic Drug in Cancer Cells

• Main Authors: Endiries Yibru Hanurry (Author), Tefera Worku Mekonnen (Author), Abegaz Tizazu Andrgie (Author), Haile Fentahun Darge (Author), Yihenew Simegniew Birhan (Author), Wei-Hsin Hsu (Author), Hsiao-Ying Chou (Author), Chih-Chia Cheng (Author), Juin-Yih Lai (Author), Hsieh-Chih Tsai (Author)
• Format: Book
• Published: MDPI AG, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Biotin receptors are overexpressed by various types of solid cancer cells and play a significant role in tumor metabolism, growth, and metastasis. Thus, targeting the biotin receptors on tumor cells may enhance the efficiency and reduce the side-effects of chemotherapy. The aim of this study was to...