Identification of differentially expressed proteins from Leishmania amazonensis associated with the loss of virulence of the parasites.

• Main Authors: Rubens D M Magalhães (Author), Mariana C Duarte (Author), Eliciane C Mattos (Author), Vivian T Martins (Author), Paula S Lage (Author), Miguel A Chávez-Fumagalli (Author), Daniela P Lage (Author), Daniel Menezes-Souza (Author), Wiliam C B Régis (Author), Maria J Manso Alves (Author), Manuel Soto (Author), Carlos A P Tavares (Author), Ronaldo A P Nagen (Author), Eduardo A F Coelho (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: The present study analyzed whether or not the in vitro cultivation for long periods of time of pre-isolated Leishmania amazonensis from lesions of chronically infected BALB/c mice was able to interfere in the parasites' infectivity using in vivo and in vitro experiments. In addition...