Evidence for in vitro and in vivo activity of the antimalarial pyronaridine against Schistosoma.

• Main Authors: Erik Koehne (Author), Nina Zander (Author), Miriam Rodi (Author), Jana Held (Author), Wolfgang Hoffmann (Author), Rella Zoleko-Manego (Author), Michael Ramharter (Author), Ghyslain Mombo-Ngoma (Author), Peter G Kremsner (Author), Andrea Kreidenweiss (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Schistosomiasis is highly prevalent in Africa. Praziquantel is effective against adult schistosomes but leaves prepatent stages unaffected-which is a limit to patient management and elimination. Given the large-scale use of praziquantel, development of drug resistance...