Oxime Therapy for Brain AChE Reactivation and Neuroprotection after Organophosphate Poisoning

• Main Authors: Darya A. Kuznetsova (Author), Gulnara A. Gaynanova (Author), Elmira A. Vasilieva (Author), Rais V. Pavlov (Author), Irina V. Zueva (Author), Vasily M. Babaev (Author), Denis M. Kuznetsov (Author), Alexandra D. Voloshina (Author), Konstantin A. Petrov (Author), Lucia Y. Zakharova (Author), Oleg G. Sinyashin (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

One of the main problems in the treatment of poisoning with organophosphorus (OPs) inhibitors of acetylcholinesterase (AChE) is low ability of existing reactivators of AChE that are used as antidotes to cross the blood-brain barrier (BBB). In this work, modified cationic liposomes were developed tha...