Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates

• Main Authors: Vidya Ramakrishnan (Author), Christina Friedrich (Author), Colleen Witt (Author), Robert Sheehan (Author), Meghan Pryor (Author), Jasvinder K. Atwal (Author), Kristin Wildsmith (Author), Katherine Kudrycki (Author), Seung‐Hye Lee (Author), Norman Mazer (Author), Carsten Hofmann (Author), Reina N. Fuji (Author), Jin Y. Jin (Author), Saroja Ramanujan (Author), Michael Dolton (Author), Angelica Quartino (Author)
• Format: Bog
• Udgivet: Wiley, 2023-01-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Abstract Despite considerable investment into potential therapeutic approaches for Alzheimer's disease (AD), currently approved treatment options are limited. Predictive modeling using quantitative systems pharmacology (QSP) can be used to guide the design of clinical trials in AD. This study d...