Age-Related Disappearance of the Inhibitory Effect of Vascular Endothelium on Agonist-Induced Vasoconstriction in Rat Mesenteric Vascular Beds

• Main Authors: Xin Jin (Author), Yukiko Satoh-Otonashi (Author), Yoshito Zamami (Author), Narumi Hobara (Author), Toshihiro Koyama (Author), Pengyuan Sun (Author), Simin Li (Author), Yoshihisa Kitamura (Author), Hiromu Kawasaki (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously reported that endothelium-derived hyperpolarizing factor (EDHF)- mediated response time-dependently suppressed methoxamine-induced vasoconstriction in mesenteric vascular beds isolated from 8-week-old rats. We investigated age-related changes in endothelial regulation of methoxamine-in...