miR-204 silencing reduces mitochondrial autophagy and ROS production in a murine AD model via the TRPML1-activated STAT3 pathway

• Ngā kaituhi matua: Lu Zhang (Author), Yu Fang (Author), Xinyu Zhao (Author), Yake Zheng (Author), Yunqing Ma (Author), Shuang Li (Author), Zhi Huang (Author), Lihao Li (Author)
• Hōputu: Pukapuka
• I whakaputaina: Elsevier, 2021-06-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Mitochondrial dysfunction is an early feature of Alzheimer's disease (AD), whereby accumulation of damaged mitochondria in conjunction with impaired mitophagy contributes to neurodegeneration. Various non-transcribed microRNAs (miRNAs) are involved in this process. In the present study, we aime...