PLGA nanoparticles for the oral delivery of nuciferine: preparation, physicochemical characterization and in vitro/in vivo studies

• Main Authors: Ying Liu (Author), Xin Wu (Author), Yushuai Mi (Author), Bimeng Zhang (Author), Shengying Gu (Author), Gaolin Liu (Author), Xiaoyu Li (Author)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

This article reports a promising approach to enhance the oral delivery of nuciferine (NUC), improve its aqueous solubility and bioavailability, and allow its controlled release as well as inhibiting lipid accumulation. NUC-loaded poly lactic-co-glycolic acid nanoparticles (NUC-PLGA-NPs) were prepare...