IGF-1 Gene Transfer to Human Synovial MSCs Promotes Their Chondrogenic Differentiation Potential without Induction of the Hypertrophic Phenotype

• मुख्य लेखकों: Yasutoshi Ikeda (लेखक), Morito Sakaue (लेखक), Ryota Chijimatsu (लेखक), David A. Hart (लेखक), Hidenori Otsubo (लेखक), Kazunori Shimomura (लेखक), Henning Madry (लेखक), Tomoyuki Suzuki (लेखक), Hideki Yoshikawa (लेखक), Toshihiko Yamashita (लेखक), Norimasa Nakamura (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Hindawi Limited, 2017-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Mesenchymal stem cell- (MSC-) based therapy is a promising treatment for cartilage. However, repair tissue in general fails to regenerate an original hyaline-like tissue. In this study, we focused on increasing the expression levels for insulin-like growth factor-1 (IGF-1) to improve repair tissue q...