IGF-1 Gene Transfer to Human Synovial MSCs Promotes Their Chondrogenic Differentiation Potential without Induction of the Hypertrophic Phenotype

• Main Authors: Yasutoshi Ikeda (Author), Morito Sakaue (Author), Ryota Chijimatsu (Author), David A. Hart (Author), Hidenori Otsubo (Author), Kazunori Shimomura (Author), Henning Madry (Author), Tomoyuki Suzuki (Author), Hideki Yoshikawa (Author), Toshihiko Yamashita (Author), Norimasa Nakamura (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mesenchymal stem cell- (MSC-) based therapy is a promising treatment for cartilage. However, repair tissue in general fails to regenerate an original hyaline-like tissue. In this study, we focused on increasing the expression levels for insulin-like growth factor-1 (IGF-1) to improve repair tissue q...