A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite

• Main Authors: Laura-Oana Albulescu (Author), Taline Kazandjian (Author), Julien Slagboom (Author), Ben Bruyneel (Author), Stuart Ainsworth (Author), Jaffer Alsolaiss (Author), Simon C. Wagstaff (Author), Gareth Whiteley (Author), Robert A. Harrison (Author), Chris Ulens (Author), Jeroen Kool (Author), Nicholas R. Casewell (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Snakebite is a neglected tropical disease that causes 138,000 deaths each year. Neurotoxic snake venoms contain small neurotoxins, including three-finger toxins (3FTxs), which can cause rapid paralysis in snakebite victims by blocking postsynaptic transmission via nicotinic acetylcholine receptors (...