SRC Kinase-Mediated Tyrosine Phosphorylation of TUBB3 Regulates Its Stability and Mitotic Spindle Dynamics in Prostate Cancer Cells

• المؤلفون الرئيسيون: Alan Alfano (مؤلف), Jin Xu (مؤلف), Xi Yang (مؤلف), Dhanraj Deshmukh (مؤلف), Yun Qiu (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2022-04-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Tubulin is an integral part of the cytoskeleton and plays a pivotal role in cellular signaling, maintenance, and division. β-tubulin is also the molecular target for taxane compounds such as docetaxel (DTX) and cabazitaxel (CTX), both first-line treatments for several solid cancers. Increased expres...