Importance of Incorporating Protein Flexibility in Molecule Modeling: A Theoretical Study on Type I1/2 NIK Inhibitors

• Main Authors: Chao Shen (Author), Hui Liu (Author), Xuwen Wang (Author), Tailong Lei (Author), Ercheng Wang (Author), Lei Xu (Author), Huidong Yu (Author), Dan Li (Author), Xiaojun Yao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

NF-κB inducing kinase (NIK), which is considered as the central component of the non-canonical NF-κB pathway, has been proved to be an important target for the regulation of the immune system. In the past few years, NIK inhibitors with various scaffolds have been successively reported, among which t...