Importance of Incorporating Protein Flexibility in Molecule Modeling: A Theoretical Study on Type I1/2 NIK Inhibitors

• প্রধান লেখক: Chao Shen (লেখক), Hui Liu (লেখক), Xuwen Wang (লেখক), Tailong Lei (লেখক), Ercheng Wang (লেখক), Lei Xu (লেখক), Huidong Yu (লেখক), Dan Li (লেখক), Xiaojun Yao (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

NF-κB inducing kinase (NIK), which is considered as the central component of the non-canonical NF-κB pathway, has been proved to be an important target for the regulation of the immune system. In the past few years, NIK inhibitors with various scaffolds have been successively reported, among which t...