Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism

• Main Authors: Jiajun Chen (Author), Tian Li (Author), Dehua Huang (Author), Wenxia Gong (Author), Junsheng Tian (Author), Xiaoxia Gao (Author), Xuemei Qin (Author), Guanhua Du (Author), Yuzhi Zhou (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chaigui granules (CG) are a compound composed of six herbal medicines with significant antidepressant effects. However, the antidepressant mechanism of CG remains unclear. In the present study, we attempted to elucidate the antidepressant mechanism of CG by regulating purine metabolism and purinergi...