Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism

• Κύριοι συγγραφείς: Jiajun Chen (Συγγραφέας), Tian Li (Συγγραφέας), Dehua Huang (Συγγραφέας), Wenxia Gong (Συγγραφέας), Junsheng Tian (Συγγραφέας), Xiaoxia Gao (Συγγραφέας), Xuemei Qin (Συγγραφέας), Guanhua Du (Συγγραφέας), Yuzhi Zhou (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2023-12-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Chaigui granules (CG) are a compound composed of six herbal medicines with significant antidepressant effects. However, the antidepressant mechanism of CG remains unclear. In the present study, we attempted to elucidate the antidepressant mechanism of CG by regulating purine metabolism and purinergi...