Mechanism of Human Urotensin II-Induced Contraction in Rat Aorta

• Main Authors: Katsunari Tasaki (Author), Masatoshi Hori (Author), Hiroshi Ozaki (Author), Hideaki Karaki (Author), Ichiro Wakabayashi (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Urotensin II induced sustained contraction with an EC50 value of 2.29 ± 0.12 nM in rat aorta. Urotensin II (100 nM) transiently increased cytosolic Ca2+ level ([Ca2+]i), followed by a small sustained phase superimposed with rhythmic oscillatory change. In the presence of verapamil and La3+, the [Ca2...