Pretargeted Imaging with Gallium-68-Improving the Binding Capability by Increasing the Number of Tetrazine Motifs

• Main Authors: Dominik Summer (Author), Sonja Mayr (Author), Milos Petrik (Author), Christine Rangger (Author), Katia Schoeler (Author), Lisa Vieider (Author), Barbara Matuszczak (Author), Clemens Decristoforo (Author)
• Format: Book
• Published: MDPI AG, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The inverse electron-demand Diels-Alder reaction between 1,2,4,5-tetrazine (Tz) and trans-cyclooct-2-ene (TCO) has gained increasing attraction among extensive studies on click chemistry due to its exceptionally fast reaction kinetics and high selectivity for in vivo pretargeting applications includ...