Amelioration of Leigh syndrome induced by mouse blastocyst complementation with a mutant human mitochondrial ATP synthase 6

• Egile Nagusiak: Huijun Yuan (Egilea), Keith A. Webster (Egilea), Muhammad Tariq Bhatti (Egilea), William W. Hauswirth (Egilea), Alfred S. Lewin (Egilea), John Guy (Egilea)
• Formatua: Liburua
• Argitaratua: Wiley, 2022-09-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract Background Mutation of the m. 8993 T > G ATP6 subunit of ATP synthase causes a maternally inherited Leigh Syndrome (LS), a rapidly fatal encephalomyelopathy in childhood called and related Neuropathy, Ataxia and Retinitis Pigmentosa (NARP) in adults. There is no cure, and relevant animal...