Whole-genome bisulfite sequencing in systemic sclerosis provides novel targets to understand disease pathogenesis

• Main Authors: Tianyuan Lu (Author), Kathleen Oros Klein (Author), Inés Colmegna (Author), Maximilien Lora (Author), Celia M. T. Greenwood (Author), Marie Hudson (Author)
• פורמט: ספר
• יצא לאור: BMC, 2019-10-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Abstract Background Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease whose pathogenesis remains incompletely understood. Increasing evidence suggests that both genetic susceptibilities and changes in DNA methylation influence pivotal biological pathways and thereby contribute...