Targeted high throughput sequencing in clinical cancer Settings: formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity

• Main Authors: Schaefer Georg (Author), Krobitsch Sylvia (Author), Herwig Ralf (Author), Sültmann Holger (Author), Timmermann Bernd (Author), Isau Melanie (Author), Kerick Martin (Author), Verdorfer Irmgard (Author), Bartsch Georg (Author), Klocker Helmut (Author), Lehrach Hans (Author), Schweiger Michal R (Author)
• Format: Book
• Published: BMC, 2011-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Massively parallel sequencing technologies have brought an enormous increase in sequencing throughput. However, these technologies need to be further improved with regard to reproducibility and applicability to clinical samples and s...