In vivo pharmacokinetic and pharmacodynamic study of co-spray-dried inhalable pirfenidone microparticles in rats

• Main Authors: Ji-Hyun Kang (Author), Min-Seok Yang (Author), Dong-Wook Kim (Author), Chun-Woong Park (Author)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Pirfenidone (PRF) is the first FDA-approved API in the treatment of idiopathic pulmonary fibrosis (IPF). However, PRF induces serious side effects, such as photophobia and gastrointestinal disorder. PRF inhalation can be expected with a lower effective dose and reduced side effects. In this study, P...