Simultaneous Determination of Five Cytochrome P450 Probe Substrates and Their Metabolites and Organic Anion Transporting Polypeptide Probe Substrate in Human Plasma Using Liquid Chromatography-Tandem Mass Spectrometry

• Váldodahkkit: Jae-Kyung Heo (Dahkki), Hyun-Ji Kim (Dahkki), Ga-Hyun Lee (Dahkki), Boram Ohk (Dahkki), Sangkyu Lee (Dahkki), Kyung-Sik Song (Dahkki), Im Sook Song (Dahkki), Kwang-Hyeon Liu (Dahkki), Young-Ran Yoon (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2018-07-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

A rapid and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous determination of organic anion transporting polypeptide 1B1 (OATP1B1) and cytochrome P450 (P450) probe substrates and their phase I metabolites in human plasma was developed. The OATP1B1 (pita...