Simultaneous Determination of Five Cytochrome P450 Probe Substrates and Their Metabolites and Organic Anion Transporting Polypeptide Probe Substrate in Human Plasma Using Liquid Chromatography-Tandem Mass Spectrometry

• Main Authors: Jae-Kyung Heo (Author), Hyun-Ji Kim (Author), Ga-Hyun Lee (Author), Boram Ohk (Author), Sangkyu Lee (Author), Kyung-Sik Song (Author), Im Sook Song (Author), Kwang-Hyeon Liu (Author), Young-Ran Yoon (Author)
• Format: Book
• Published: MDPI AG, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A rapid and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous determination of organic anion transporting polypeptide 1B1 (OATP1B1) and cytochrome P450 (P450) probe substrates and their phase I metabolites in human plasma was developed. The OATP1B1 (pita...