Simultaneous Determination of Five Cytochrome P450 Probe Substrates and Their Metabolites and Organic Anion Transporting Polypeptide Probe Substrate in Human Plasma Using Liquid Chromatography-Tandem Mass Spectrometry

• Autors principals: Jae-Kyung Heo (Autor), Hyun-Ji Kim (Autor), Ga-Hyun Lee (Autor), Boram Ohk (Autor), Sangkyu Lee (Autor), Kyung-Sik Song (Autor), Im Sook Song (Autor), Kwang-Hyeon Liu (Autor), Young-Ran Yoon (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2018-07-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

A rapid and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous determination of organic anion transporting polypeptide 1B1 (OATP1B1) and cytochrome P450 (P450) probe substrates and their phase I metabolites in human plasma was developed. The OATP1B1 (pita...