Rare RNF213 variants and the risk of intracranial artery stenosis/occlusion disease in Chinese population: a case-control study

• Main Authors: Xin Liao (Author), Tong Zhang (Author), Bingyang Li (Author), Shimin Hu (Author), Junyu Liu (Author), Jing Deng (Author), Hongzhuan Tan (Author), Junxia Yan (Author)
• Format: Book
• Published: BMC, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background RNF213 rare variant-p.R4810K (rs112735431) was significantly associated with intracranial artery stenosis/occlusion disease (ICASO) in Japan and Korea and to a lesser degree in China. Considering the allelic heterogeneity, we performed target exome sequencing of RNF213 with the a...