Optimization of Innovative Three-Dimensionally-Structured Hybrid Vesicles to Improve the Cutaneous Delivery of Clotrimazole for the Treatment of Topical Candidiasis

• Main Authors: Maria Letizia Manca (Author), Iris Usach (Author), José Esteban Peris (Author), Antonella Ibba (Author), Germano Orrù (Author), Donatella Valenti (Author), Elvira Escribano-Ferrer (Author), Juan Carmelo Gomez-Fernandez (Author), Francisco José Aranda (Author), Anna Maria Fadda (Author), Maria Manconi (Author)
• Format: Book
• Published: MDPI AG, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

New three-dimensionally-structured hybrid phospholipid vesicles, able to load clotrimazole in a high amount (10 mg/mL), were obtained for the first time in this work by significantly reducing the amount of water (≤10%), which was replaced with a mixture of glycerol and ethanol (≈90%). A pre-formulat...