Antibacterial Activity of T22, a Specific Peptidic Ligand of the Tumoral Marker CXCR4

• Main Authors: Naroa Serna (Author), José Vicente Carratalá (Author), Oscar Conchillo-Solé (Author), Carlos Martínez-Torró (Author), Ugutz Unzueta (Author), Ramón Mangues (Author), Neus Ferrer-Miralles (Author), Xavier Daura (Author), Esther Vázquez (Author), Antonio Villaverde (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CXCR4 is a cytokine receptor used by HIV during cell attachment and infection. Overexpressed in the cancer stem cells of more than 20 human neoplasias, CXCR4 is a convenient antitumoral drug target. T22 is a polyphemusin-derived peptide and an effective CXCR4 ligand. Its highly selective CXCR4 bindi...