Expanded Physiologically‐Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction

• मुख्य लेखकों: Ryuta Asaumi (लेखक), Karsten Menzel (लेखक), Wooin Lee (लेखक), Ken‐ichi Nunoya (लेखक), Haruo Imawaka (लेखक), Hiroyuki Kusuhara (लेखक), Yuichi Sugiyama (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2019-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

As rifampicin can cause the induction and inhibition of multiple metabolizing enzymes and transporters, it has been challenging to accurately predict the complex drug-drug interactions (DDIs). We previously constructed a physiologically‐based pharmacokinetic (PBPK) model of rifampicin accounting for...