Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Regulation of Dopaminergic Neural Transmission by Tyrosine Hydroxylase Protein at Nerve Terminals

• Glavni autori: Chiho Sumi-Ichinose (Autor), Hiroshi Ichinose (Autor), Kazuhisa Ikemoto (Autor), Takahide Nomura (Autor), Kazunao Kondo (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2010-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

5R-l-Erythro-5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for tyrosine hydroxylase (TH). Recently, a type of dopa-responsive dystonia (DRD) (DYT5, Segawa's disease) was revealed to be caused by dominant mutations of the gene encoding GTP cyclohydrolase I (GCHI), which is the rate-...