Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Regulation of Dopaminergic Neural Transmission by Tyrosine Hydroxylase Protein at Nerve Terminals

5R-l-Erythro-5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for tyrosine hydroxylase (TH). Recently, a type of dopa-responsive dystonia (DRD) (DYT5, Segawa's disease) was revealed to be caused by dominant mutations of the gene encoding GTP cyclohydrolase I (GCHI), which is the rate-...

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Main Authors: Chiho Sumi-Ichinose (Author), Hiroshi Ichinose (Author), Kazuhisa Ikemoto (Author), Takahide Nomura (Author), Kazunao Kondo (Author)
Format: Book
Published: Elsevier, 2010-01-01T00:00:00Z.
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