Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain

Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain

Hyperactive mutation V617F in the JAK2 regulatory pseudokinase domain (JH2) is prevalent in patients with myeloproliferative neoplasms. Here, we identified novel small molecules that target JH2 of JAK2 V617F and characterized binding via biochemical and structural approaches. Screening of 107,600 sm...

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Main Authors: Anniina T. Virtanen (Author), Teemu Haikarainen (Author), Parthasarathy Sampathkumar (Author), Maaria Palmroth (Author), Sanna Liukkonen (Author), Jianping Liu (Author), Natalia Nekhotiaeva (Author), Stevan R. Hubbard (Author), Olli Silvennoinen (Author)
Format: Book
Published: MDPI AG, 2023-01-01T00:00:00Z.
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