The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway

• Main Authors: Zhiqi Li (Author), Qiqi Fan (Author), Meilin Chen (Author), Ying Dong (Author), Farong Li (Author), Mingshuang Wang (Author), Yulin Gu (Author), Simin Guo (Author), Xianwen Ye (Author), Jiarui Wu (Author), Shengyun Dai (Author), Ruichao Lin (Author), Chongjun Zhao (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polyphyllin I (PPI) and polyphyllin II (PII) are the main active substances in the Paris polyphylla. However, liver toxicity of these compounds has impeded their clinical application and the potential hepatotoxicity mechanisms remain to be elucidated. In this work, we found that PPI and PII exposure...