Pgc-1α repression and high-fat diet induce age-related macular degeneration-like phenotypes in mice

• Main Authors: Meng Zhang (Author), Yi Chu (Author), Joseph Mowery (Author), Brandon Konkel (Author), Susana Galli (Author), Alexander C. Theos (Author), Nady Golestaneh (Author)
• Format: Book
• Published: The Company of Biologists, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Age-related macular degeneration (AMD) is the major cause of blindness in the elderly in developed countries and its prevalence is increasing with the aging population. AMD initially affects the retinal pigment epithelium (RPE) and gradually leads to secondary photoreceptor degeneration. Recent stud...