Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS

Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS

Adeno-associated virus (AAV) is the most common vector for clinical gene therapy of the CNS. This popularity originates from a high safety record and the longevity of transgene expression in neurons. Nevertheless, clinical efficacy for CNS indications is lacking, and one reason for this is the relat...

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Main Authors: Nicholas M. Kanaan (Author), Rhyomi C. Sellnow (Author), Sanford L. Boye (Author), Ben Coberly (Author), Antonette Bennett (Author), Mavis Agbandje-McKenna (Author), Caryl E. Sortwell (Author), William W. Hauswirth (Author), Shannon E. Boye (Author), Fredric P. Manfredsson (Author)
Format: Book
Published: Elsevier, 2017-09-01T00:00:00Z.
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3rd Floor Main Library

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