Hydrogel Formulations Incorporating Drug Nanocrystals Enhance the Therapeutic Effect of Rebamipide in a Hamster Model for Oral Mucositis

• Main Authors: Noriaki Nagai (Author), Ryotaro Seiriki (Author), Saori Deguchi (Author), Hiroko Otake (Author), Noriko Hiramatsu (Author), Hiroshi Sasaki (Author), Naoki Yamamoto (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A mouthwash formulation of rebamipide (REB) is commonly used to treat oral mucositis; however, this formulation does not provide sufficient treatment or prevention in cases of serious oral mucositis. To improve treatment, we attempted to design a hydrogel incorporating REB nanocrystals (R-NPs gel)....