Subchronic <i>N</i>-acetylcysteine Treatment Decreases Brain Kynurenic Acid Levels and Improves Cognitive Performance in Mice

• Main Authors: Tonali Blanco Ayala (Author), Daniela Ramírez Ortega (Author), Paulina Ovalle Rodríguez (Author), Benjamín Pineda (Author), Gonzalo Pérez de la Cruz (Author), Dinora González Esquivel (Author), Robert Schwarcz (Author), Korrapati V. Sathyasaikumar (Author), Anabel Jiménez Anguiano (Author), Verónica Pérez de la Cruz (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The tryptophan (Trp) metabolite kynurenic acid (KYNA) is an α7-nicotinic and <i>N</i>-methyl-<span style="font-variant: small-caps;">d</span>-aspartate receptor antagonist. Elevated brain KYNA levels are commonly seen in psychiatric disorders and neurodegenerative d...