Proteomic analysis of urine exosomes reveals renal tubule response to leptospiral colonization in experimentally infected rats.

• Main Authors: Satish P RamachandraRao (Author), Michael A Matthias (Author), Chanthel Kokoy-Mondragon (Author), Eamon Aghania (Author), Cathleen Park (Author), Casey Kong (Author), Michelle Ishaya (Author), Assael Madrigal (Author), Jennifer Horng (Author), Roni Khoshaba (Author), Anousone Bounkhoun (Author), Fabrizio Basilico (Author), Antonella De Palma (Author), Anna Maria Agresta (Author), Linda Awdishu (Author), Robert K Naviaux (Author), Joseph M Vinetz (Author), Pierluigi Mauri (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Infectious Leptospira colonize the kidneys of reservoir (e.g. rats) and accidental hosts such as humans. The renal response to persistent leptospiral colonization, as measured by urinary protein biosignatures, has not been systematically studied. Urinary exosomes--bioactive membrane-bound nanovesicl...