A quantitative systems pharmacology approach to predict the safe‐equivalent dose of doxorubicin in patients with cardiovascular comorbidity

• Main Authors: Lan Sang (Author), Yi Yuan (Author), Ying Zhou (Author), Zhengying Zhou (Author), Muhan Jiang (Author), Xiaoquan Liu (Author), Kun Hao (Author), Hua He (Author)
• Format: Book
• Published: Wiley, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Patients with cardiovascular comorbidity are less tolerant to cardiotoxic drugs and should be treated with reduced doses to prevent cardiotoxicity. However, the safe‐equivalent dose of antitumor drugs in patients with cardiovascular disease/risk is difficult to predict because they are usua...