Cover Image

Mechanisms of Piperacillin/Tazobactam Nephrotoxicity: Piperacillin/Tazobactam-Induced Direct Tubular Damage in Mice

Piperacillin/tazobactam (PT) is one of the most commonly prescribed antibiotics for critically ill patients in intensive care. PT has been reported to cause direct nephrotoxicity; however, the underlying mechanisms remain unknown. We investigated the mechanisms underlying PT nephrotoxicity using a m...

Full description

Saved in:

Bibliographic Details
Main Authors:	Jihyun Yang (Author), Yoon Sook Ko (Author), Hee Young Lee (Author), Yina Fang (Author), Se Won Oh (Author), Myung-Gyu Kim (Author), Won Yong Cho (Author), Sang-Kyung Jo (Author)
Format:	Book
Published:	MDPI AG, 2023-06-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Piperacillin/Tazobactam (ZOSYN)
by: Stephanie M. Culver, et al.
Published: (1996)

The role of piperacillin/tazobactam in the treatment of Hidradenitis suppurativa
by: Aviv Barzilai, et al.
Published: (2024)

Comparison of Cefepime with Piperacillin/Tazobactam Treatment in Patients with Hospital-Acquired Pneumonia
by: Bo-Guen Kim, et al.
Published: (2023)

Piperacillin/Tazobactam as Cause of Acute Generalized Exanthematous Pustulosis
by: Aikaterini Kyriakou, et al.
Published: (2019)

Piperacillin/tazobactam treatment in children: evidence of subtherapeutic concentrations
by: Panpan Ye, et al.
Published: (2024)

Evaluation of Strategies for Reducing Vancomycin-Piperacillin/Tazobactam Incompatibility
by: Anthony Martin Mena, et al.
Published: (2023)

Piperacilina/tazobactam en el sistema VITEK ®2 Piperacillin / Tazobactam in the VITEk ®2 System
by: Javier Gutman, et al.
Published: (2011)

The impact of a best practice advisory on inpatient prescribing of piperacillin-tazobactam
by: Katherine L. Peterson, et al.
Published: (2022)

Incidence and Determinants of Piperacillin/Tazobactam-Associated Hypokalemia: A Retrospective Study
by: Heenam Seo, et al.
Published: (2022)

Comparison of Piperacillin and Tazobactam Pharmacokinetics in Critically Ill Patients with Trauma or with Burn
by: Daniel J. Selig, et al.
Published: (2022)

Activity Of Piperacillin/Tazobactam And Cefoperazone/Sulbactam Against Pathogenic Isolates Of Enterobacteriaceae
by: Qamar un nisa Naz, et al.
Published: (2024)

Simple HPLC-UV Method for Piperacillin/Tazobactam Assay in Human Plasma
by: Khaled Abdelkawy, et al.
Published: (2023)

Synthesis and evaluation of polymeric micelle containing piperacillin/tazobactam for enhanced antibacterial activity
by: Milani Morteza, et al.
Published: (2019)

Evaluation of Piperacillin/Sulbactam, Piperacillin/Tazobactam and Cefoperazone/Sulbactam Dosages in Gram-Negative Bacterial Bloodstream Infections by Monte Carlo Simulation
by: Xueting Wang, et al.
Published: (2023)

Piperacillin-Tazobactam as an Adjuvant in the Mechanical Treatment of Patients with Periodontitis: A Randomized Clinical Study
by: Dolores Hurtado-Celotti, et al.
Published: (2022)

Electrolyte Disorders Associated with Piperacillin/Tazobactam: A Pharmacovigilance Study Using the FAERS Database
by: Heenam Seo, et al.
Published: (2023)

Acute Kidney Injury in Pediatric Treated with Vancomycin and Piperacillin-Tazobactam in Tertiary Care Hospital
by: Mohammed Al Nuhait, et al.
Published: (2018)

Evaluation of Piperacillin/Tazobactam Use and Resistance Pattern in a Teaching Hospital, Northwest Iran
by: Afshin Shiva, et al.
Published: (2022)

Penetration of Piperacillin/Tazobactam Into Gynecologic Tissues Following a Single Loading Dose Prior to Hysterectomy
by: William F. O'Brien, et al.
Published: (1994)

Pilot study evaluating intravenous amoxicillin-clavulanate as an alternative to piperacillin-tazobactam for general surgery patients
by: Sarah A. Drost, et al.
Published: (2023)

Superinfection rate among the patients treated with carbapenem versus piperacillin/tazobactam: Retrospective observational study
by: Hessa Al Muqati, et al.
Published: (2021)

Comparison of the incidence of acute kidney injury during treatment with vancomycin in combination with piperacillin-tazobactam or with meropenem
by: Majed S. Al Yami
Published: (2017)

Clinical effectiveness of branded versus generic piperacillin-tazobactam for treating severe community-acquired pneumonia
by: Cheng-Yi Wang, et al.
Published: (2022)

Evaluation of the Impact of Infusion Set Design on the Particulate Load Induced by Vancomycin-Piperacillin/Tazobactam Incompatibility
by: Laura Négrier, et al.
Published: (2024)

Evaluating the appropriateness of carbapenem and piperacillin-tazobactam prescribing in a tertiary care hospital in Saudi Arabia
by: Nada A Alsaleh, et al.
Published: (2020)

Antistaphylococcal Efficacy of Cefepime, Meropenem, and Piperacillin-Tazobactam in Patients with Polymicrobial Infection with MSSA Bacteremia or Pneumonia
by: Laila M. Najia, et al.
Published: (2023)

Continuous Piperacillin-Tazobactam Infusion Improves Clinical Outcomes in Critically Ill Patients with Sepsis: A Retrospective, Single-Centre Study
by: Dong-gon Hyun, et al.
Published: (2022)

Initial blood culture collection practices and the associated factors upon continued empiric piperacillin-tazobactam usage
by: Satoshi Kitaura, et al.
Published: (2023)

Piperacillin/Tazobactam Co-Delivery by Micellar Ionic Conjugate Systems Carrying Pharmaceutical Anions and Encapsulated Drug
by: Katarzyna Niesyto, et al.
Published: (2024)

Evaluation Outcomes Associated with Alternative Dosing Strategies for Piperacillin/Tazobactam: A Systematic Review and Meta-Analysis
by: Hui Yang, et al.
Published: (2016)

Frequency of Acute Kidney Injury in Patient Receiving Piperacillin - Tazobactam: A Hospital-based Study from Qatar
by: Fahmi Yousef Khan, et al.
Published: (2021)

BIChromET: A Chromogenic Culture Medium for Detection of Piperacillin/Tazobactam and Cefepime Resistance in <i>Pseudomonas aeruginosa</i>
by: José Manuel Ortiz de la Rosa, et al.
Published: (2023)

Population Pharmacokinetic Modeling and Pharmacodynamic Target Attainment Simulation of Piperacillin/Tazobactam for Dosing Optimization in Late Elderly Patients with Pneumonia
by: Noriyuki Ishihara, et al.
Published: (2020)

Piperacillin enhances the inhibitory effect of tazobactam on β-lactamase through inhibition of organic anion transporter 1/3 in rats
by: Shilei Yang, et al.
Published: (2019)

Drug Utilization Evaluation and Impact of Pharmacist Interventions on Optimization of Piperacillin/Tazobactam Use: A Retrospective Analysis and Prospective Audit
by: Savera Arain, et al.
Published: (2023)

Pharmacokinetics and outcome of tazobactam/piperacillin in Japanese patients undergoing low-flow continuous renal replacement therapy: dosage considerations
by: Kohama H, et al.
Published: (2017)

Drug Utilization Evaluation of Two Broad-Spectrum Antimicrobials: Cefepime and Piperacillin/Tazobactam in a Teaching Hospital in Tabriz, Iran
by: Parviz Saleh, et al.
Published: (2019)

Similar Piperacillin/Tazobactam Target Attainment in Obese versus Nonobese Patients despite Differences in Interstitial Tissue Fluid Pharmacokinetics
by: David Busse, et al.
Published: (2021)

Retrospective evaluation of piperacillin-tazobactam, imipenem-cilastatin and meropenem used on surgical floors at a tertiary care hospital in Saudi Arabia
by: Eman Youssif, et al.
Published: (2018)

The Infusion of Piperacillin/Tazobactam with an Elastomeric Device: A Combined 24-H Stability Study and Drug Solution Flow Rate Analysis
by: Laura Négrier, et al.
Published: (2024)