Inflammation altered correlation between CYP2C19 genotype and CYP2C19 activity in patients receiving voriconazole

• Main Authors: Sylvia D. Klomp (Author), Anette Veringa (Author), Jan‐Willem C. Alffenaar (Author), Mark G. J. deBoer (Author), Lambert F. R. Span (Author), Henk‐Jan Guchelaar (Author), Jesse J. Swen (Author)
• Format: Book
• Published: Wiley, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Voriconazole is the cornerstone of the treatment and prevention of fungal infections. While there is a good correlation between CYP2C19 genotype and voriconazole exposure during prophylactic treatment, no correlation was found in patients with invasive aspergillosis. Proinflammatory cytokin...