Acquisition of rifabutin resistance by a rifampicin resistant mutant of <it>Mycobacterium tuberculosis </it>involves an unusual spectrum of mutations and elevated frequency

• Main Authors: Oskam Linda (Author), Brown Tim J (Author), Bergval Indra L (Author), Schuitema Anja RJ (Author), Anthony Richard M (Author), Klatser Paul R (Author)
• Format: Book
• Published: BMC, 2005-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Mutations in a small region of the <it>rpoB </it>gene are responsible for most rifamycin resistance in <it>Mycobacterium tuberculosis</it>. In this study we have sequentially generated resistant strains to fir...