Investigating the Central Nervous System Disposition of Actinomycin D: Implementation and Evaluation of Cerebral Microdialysis and Brain Tissue Measurements Supported by UPLC-MS/MS Quantification

• Main Authors: Julia Benzel (Author), Gzona Bajraktari-Sylejmani (Author), Philipp Uhl (Author), Abigail Davis (Author), Sreenath Nair (Author), Stefan M. Pfister (Author), Walter E. Haefeli (Author), Johanna Weiss (Author), Jürgen Burhenne (Author), Kristian W. Pajtler (Author), Max Sauter (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Actinomycin D is a potent cytotoxic drug against pediatric (and other) tumors that is thought to barely cross the blood-brain barrier. To evaluate its potential applicability for the treatment of patients with central nervous system (CNS) tumors, we established a cerebral microdialysis model in free...