Increased Sclerostin, but Not Dickkopf-1 Protein, Is Associated with Elevated Pulse Wave Velocity in Hemodialysis Subjects

• Main Authors: Eirini Stavrinou (Author), Pantelis A. Sarafidis (Author), Charalampos Koumaras (Author), Charalampos Loutradis (Author), Panagiotis Giamalis (Author), Konstantinos Tziomalos (Author), Asterios Karagiannis (Author), Aikaterini Papagianni (Author)
• Format: Book
• Published: Karger Publishers, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Sclerostin and Dickkopf-1 (Dkk-1) proteins are inhibitors of the canonical Wnt/β-catenin bone pathway. Pilot data suggest that sclerostin may be involved in vascular changes in chronic kidney disease (CKD), but data on the effects of Dkk-1 are scarce. This is the first study investigatin...